In vitro analyses of ethanol activity against Candida albicans biofilms.

نویسندگان

  • Hallie S Rane
  • Stella M Bernardo
  • Carla J Walraven
  • Samuel A Lee
چکیده

Candida albicans is a common cause of catheter-related bloodstream infections (CR-BSI). Ethanol (EtOH) lock therapy has been attempted despite limited data on optimal dose and duration. Concentrations of 35% EtOH or higher for a minimum of 4 h demonstrated a >99% reduction in mature C. albicans biofilm metabolic activity and prevented regrowth. Concentrations of 10% EtOH or higher reduced C. albicans biofilm formation by >99%. Further investigation of EtOH lock therapy for treatment and prevention of C. albicans CR-BSI is warranted.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 56 8  شماره 

صفحات  -

تاریخ انتشار 2012